The Moses Gamble House was built around 1892 by Nathan Boyd, a skilled cabinetmaker whose shop was located on Church Street. One of the original owners was Moses H. Gamble (1871-1934), who served in the state House of Representatives, the state Senate and as Chancellor of the Thirteenth Chancery Court of Blount County.

The Maryville Daily Times describes the Gamble House: "A graceful home standing at the corner of Gamble and Cates streets in Maryville beckons visitors with an old-fashioned charm.  The front porch and its rocking chairs bring visions of quiet Sundays filled with the fellowship of passing friends.  Huge maples dapple the lawn with shade in the summer and colorful leaves in the fall. The quiet Southern charm continues into the house itself with the original hardwood floors, arched doorways and working fireplaces.  Photographs are displayed on the mantels and the parlor furnishings are in keeping with what may have been in the house when its earliest residents lived there almost 115 years ago."